Siskiyou County /ˈsɪskjuː/ siss-kew is a county located in the northernmost part of the U.S. state of California.
The 2010 United States Census reported that Siskiyou County had a population of 44,900.
Siskiyou County is located in the Shasta Cascade region along the Oregon border. Because of its outdoor recreation opportunities and Gold Rush era history, it is an important tourist destination within the state.Siskiyou is a strongly Republican county in Presidential and congressional elections. The last Democrat to win a majority in the county was Lyndon Johnson in 1964.